Last Updated on Sunday, 19 January 2014 13:06
*Department of Medicine, University of Ilorin Teaching Hospital Ilorin, Kwara State, Nigeria Department of Medicine, LAUTECH, Osogbo Osun State
Correspondence to:Dr. Emmanuel O. Sanya PO Box 5314 Ilorin Kwara State, Nigeria
Last Updated on Sunday, 19 January 2014 13:11
*Department of Community Health and Primary Health Care,
#Department of Paediatrics and Child Health,
Lagos State University College of Medicine, P M B 21266 Ikeja, Lagos, Nigeria
+GlaxoSmithKline Vaccines, Wavre, Belgium
Correspondence to : Olumuyiwa O. Odusanya, Telephone: +234 1 878 3167.
Summary Aims and Objectives: The immunogenicity, reactogenicity and safety of the 10- valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) were evaluated in a cohort of Nigerian infants included in a study conducted in Mali and Nigeria (ClinicalTrials.gov identifier: NCT00678301). Subjects and Methods In this open, randomised, controlled study, 119 healthy infants received combined diphtheria-tetanus-whole-cell pertussis-hepatitis B/ Haemophilus influenzae type b vaccine (DTPw-HBV/Hib) and oral poliovirus vaccine (OPV) co-administered with PHiD-CV (PHiD-CV group) or without PHiD-CV (control group) at 6-10-14 weeks of age. Pneumococcal antibody responses and opsonophagocytic activity were measured and adverse events were recorded. Results: One month post-dose 3, for each of the vaccine pneumococcal serotypes, e”90.1% of PHiD-CV recipients had an antibody concentration e”0.2 μg/mL compared to <9% (except for serotypes 14 [32.4%] and 19F [27.8%]) in the control group. For each of the vaccine pneumococcal serotypes, e”90.6% of infants in the PHiD-CV group had an OPA titre e”8, compared to <18% (except for serotype 7F [60.0%]) in the control group. Anti-protein D antibody geometric mean antibody concentrations were 2949.7 EL.U/mL in the PHiD-CV group and 68.9 EL.U/mL in the control group. For each DTPw-HBV/Hib antigen antibody seroprotection/seropositivity rates were e”94.4%. Tolerability was generally comparable between the PHiD-CV and control vaccination groups. Conclusions: PHiD-CV co-administered with routine vaccines was immunogenic for all vaccine pneumococcal serotypes and protein D in Nigerian infants. Vaccine tolerability was generally comparable between the PHiD-CV and control groups. These results suggest PHiD-CV can be co-administered with other vaccines included in the National Programme on Immunisation.
Last Updated on Sunday, 19 January 2014 13:13
Department of Community Medicine, Jos University Teaching Hospital, Jos Nigeria.
P.M.B 2076 Jos, Plateau State Nigeria
Dr Daboer JC.
Aims and Objectives: After the initial gains in Tuberculosis case detection and cure rates, progress became stunted by persisting constraints and challenges in the implementation of the Directly Observed Treatment Short course strategy. This prompted the Stop Tuberculosis partners in 2006 to adopt innovative approaches including the Public-Private Mix, to improve access to and quality of care. This paper assesses the level of Public-Private Mix in Tuberculosis control in Jos, Plateau State.
Materials and Methods: This was a facility-based, cross sectional study where data from all consenting private health care facilities owned by medically trained personnel and private medical practitioners in Jos North and Jos South Local Government Areas was collected using structured questionnaires.
Results: Eight (47.1%) of all 17 facilities assessed gave anti Tuberculosis drugs on clinical suspicion of Tuberculosis, 5(29.4%) required Acid Fast Bacillus result and 3(17.6%) referred elsewhere for the Tuberculosis management. Only 6 facilities (35.3%) were microscopy, treatment centres, or both. Ten (58.8%) of the facilities had the Directly Observed Treatment Short course guidelines, but these could be sighted in only 5 (29.4%), while six (35.3%) had Tuberculosis record and referral forms. In 13 (76.5%) of the facilities, no local government Tuberculosis and Leprosy supervisors had ever visited them. Only 30 (57.7%) medical practitioners had access to the Directly Observed Treatment Short course. Thirty two (61.5%) respondents treated Tuberculosis according to the Directly Observed Treatment Short course strategy, but 19 (36.5%) still used the conventional method. Only 22(42.3%) practitioners had ever received any training on the Directly Observed Treatment Short course strategy. Conclusion: The level of Public-Private Mix in Tuberculosis control in Jos is low.
Key words: Private Medical Practitioners, Tuberculosis Control, DOTS
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